| 角色 | 演员 |
| Sheriff Ed Tom Bell | 汤米·李·琼斯Tommy Lee Jones |
| Anton Chigurh | 哈维尔·巴登Javier Bardem |
| Llewelyn Moss | 乔什·布洛林Josh Brolin |
| Carson Wells | 伍迪·哈里森Woody Harrelson |
| Carla Jean Moss | 凯莉·麦克唐纳Kelly Macdonald |
| Deputy Wendell | 加瑞特·迪拉胡特Garret Dillahunt |
| Loretta Bell | 泰丝·哈珀Tess Harper |
| Ellis | 巴里·柯宾Barry Corbin |
| Man who hires Wells | 斯蒂芬·鲁特Stephen Root |
| Sheriff Roscoe Giddens | Rodger Boyce |
| Carla Jean's Mother | 贝丝·格兰特Beth Grant |
| Poolside Woman | Ana Reeder |
| Sheriff Bell's Secretary | Kit Gwin |
| Strangled Deputy | Zack Hopkins |
| Man in Ford | Chip Love |
| 'Agua' Man | Eduardo Antonio Garcia |
| Gas Station Proprietor | Gene Jones |
| 'Managerial' Victim #1 | Myk Watford |
| 'Managerial' Victim #2 | Boots Southerland |
| Desert Aire Manager | 凯茜·拉姆金Kathy Lamkin |
| Cabbie at Bus Station | Johnnie Hector |
| Del Rio Motel Clerk | Margaret Bowman |
| Boot Salesman | Thomas Kopache |
| Cabbie at Motel | 杰森·道格拉斯Jason Douglas |
| Waitress | Doris Hargrave |
| Gun Store Clerk | Rutherford Cravens |
| Sporting Goods Clerk | Matthew Posey |
| Mexican in Bathtub | George Adelo |
| Hitchhiking Driver | Mathew Greer |
| Nervous Accountant | Trent Moore |
| Hotel Eagle Clerk | Marc Miles |
| Pickup Driver | Luce Rains |
| Border Bridge Youth #1 | Philip Bentham |
| Border Bridge Youth #2 | Eric Reeves |
| Border Bridge Youth #3 | Joshua Meyer |
| Flatbed Driver | Chris Warner |
| INS Official | Brandon Smith |
| Well Dressed Mexican (as H. Roland Uribe) | Roland Uribe |
| Chicken Farmer | Richard Jackson |
| Boy on Bike #1 | Josh Blaylock |
| Boy on Bike #2 | 卡赖伯·兰德里·琼斯Caleb Landry Jones |
| Odessa Cabbie | Dorsey Ray |
| Cab Driver (uncredited) | Scott Flick |
| Nurse (uncredited) | Elizabeth Slagsvol |
